Evaluation of high molecular weight cytokeratin (HMWCK), p27, C-X-C chemokine receptor type 4 (CXCR-4) and stromal cell-derived factor 1 (SDF-1) expressions related to tumor progression in breast cancer

Authors : Gonca ÖZGÜN, Gülen AKYOL

Pages : 800-808

Doi:10.18621/eurj.423593

View : 25 | Download : 15

Publication Date : 2019-09-04

Article Type : Research Paper

Abstract :Objectives: Breast cancer is the most common cancer and the most common reason for cancer death in women population. The immunohistochemical markers which could have prognostic information are always needed. Methods: This study included 365 cases of invasive ductal carcinoma insert ignore into journalissuearticles values(IDC);, ductal carcinoma in situ insert ignore into journalissuearticles values(DCIS); and ductal epithelial hyperplasia. The cases divided into the following two groups according to the presence of cancer: 1); cancer group insert ignore into journalissuearticles values(298 cases; cases with IDC and DCIS);, 2); non-cancer group insert ignore into journalissuearticles values(67 cases without cancer; cases with usual ductal epithelial hyperplasia [UDH] and atypical ductal epithelial hyperplasia [ADH] );. All histological slides stained with high molecular weight cytokeratin insert ignore into journalissuearticles values(HMWCK); , p27, C-X-C chemokine receptor type 4 insert ignore into journalissuearticles values(CXCR-4);, stromal cell-derived factor 1 insert ignore into journalissuearticles values(SDF-1); immunohistochemically. Results: IDC was present in 277 cases, of which 213 had pure IDC, and 64 had DCIS component adjacent to the invasive tumor. Twenty-one cases had only DCIS. Of 67 cases with epithelial hyperplasia, 31 had ADH, and 36 had UDH. Among cases with IDC, 143 had lymph node excision, of which 73 had metastasis in one or more lymph nodes, and 70 did not have metastatic disease. The expression of p27 was found to be significantly lower in the cancer group as compared to that in the non-cancer group insert ignore into journalissuearticles values( p < 0.0001);. CXCR-4 expression in IDC was found to be higher than that of DCIS group. SDF-1 expression was observed to be significantly higher in cancer cases than that of non-cancer cases insert ignore into journalissuearticles values( p = 0.03);. Conclusions: T he higher CXCR-4 and SDF-1 expressions are associated with tumor progression, tumor size, and lymph node status. In benign proliferative lesions, both HMWK and p27 expressions were helpful in differential diagnosis of borderline atypical ductal hyperplasia and DCIS. 
Keywords : CXCR 4, SDF 1, p27, HMWCK, benign proliferative breast lesions, ductal carcinoma in situ, invasive ductal carcinoma, tissue microarray