The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients

Authors : Nizameddin KOCA, Alparslan ERSOY, Barış ŞENSOY, Emine KIRHAN, Sümeyye GÜLLÜLÜ, Melahat DİRİCAN, Emre SARANDÖL

Pages : 836-846

Doi:10.18621/eurj.572606

View : 17 | Download : 12

Publication Date : 2019-09-04

Article Type : Research Paper

Abstract :Objectives: Kidney transplantation recipients insert ignore into journalissuearticles values(KTRs); have higher cardiovascular complications risk compared to the general population. Cardiovascular risk factors insert ignore into journalissuearticles values(CVRF, Traditional and non-traditional); are widely studied to understand the causes of increased cardiovascular disease insert ignore into journalissuearticles values(CVD); risk in KTRs. Fetuin-A prevents from vascular calcification insert ignore into journalissuearticles values(VC); by inhibiting production and collapsing of apatite crystals to the vascular wall. The relationship between fetuin-A levels and CVRF in KTRs was investigated in this study. Methods: Sixty-two KTRs with no prior CVD history participated. Anthropometrical, laboratory insert ignore into journalissuearticles values(fetuin-A, inflammation markers, antioxidants, lipid peroxidation products); and cardiological insert ignore into journalissuearticles values(echocardiographic, pulse wave velocity); measurements were performed. Participants were divided into two groups according to normal insert ignore into journalissuearticles values(≥ 0.5 g/L, n = 32, NFA); and low insert ignore into journalissuearticles values(< 0.5 g/L, n = 30, LFA); fetuin-A levels according to manufacturer’s reference range, and the results were compared. Results: No significant difference was observed in demographic features, body mass index, systolic and diastolic blood pressures, left ventricle mass index, waist and hip circumferences, left ventricle hypertrophy and waist-hip ratios between the two groups insert ignore into journalissuearticles values( p > 0.05);. The ratios of drug usage such as immunosuppressives, anti-hypertensives and statin were comparable between two groups.  Parathormone levels were significantly higher in the NFA group insert ignore into journalissuearticles values( p = 0.015); and glomerular filtration rate was calculated significantly higher in LFA group insert ignore into journalissuearticles values( p = 007);. The comparison of other CVRF reveals no significant difference insert ignore into journalissuearticles values( p > 0.05);. Conclusions: Although many CVRF improved in KTRs, subclinical inflammation markers were still higher than the healthy population. Identification and early recognition of CVRF in high-risk individuals may contribute to the reduction of cardiovascular mortality. In our study, we observed no significant relationship between fetuin-A levels and CVRFs.  We evaluated the relationship between serum fetuin-A levels on cardiovascular risk factors by its role in pathophysiology. 
Keywords : Kidney transplantation, cardiovascular risk factor, fetuin A