The effect of electroconvulsive therapy on hematologic inflammatory markers in schizophrenia in association with type of antipsychotic medication

Authors : Sinay ÖNEN, İbrahim TAYMUR

Pages : 238-247

Doi:10.18621/eurj.586551

View : 24 | Download : 10

Publication Date : 2020-05-04

Article Type : Research Paper

Abstract :Objectives: In recent years there has been an increased interest on the role of inflammation in the pathophysiology of schizophrenia and a search for readily applicable prognostic markers. The impact of electroconvulsive therapy insert ignore into journalissuearticles values(ECT); on inflammatory function in schizophrenia is still unclear. The aim of this retrospective study is to compare pre- and post-ECT values of red cell distribution width insert ignore into journalissuearticles values(RDW);, mean platelet volume insert ignore into journalissuearticles values(MPV);, mean cell hemoglobin insert ignore into journalissuearticles values(MCH);, mean cell hemoglobin concentration insert ignore into journalissuearticles values(MCHC);, neutrophil-to-lymphocyte ratio insert ignore into journalissuearticles values(NLR); and platelet-to-lymphocyte ratio insert ignore into journalissuearticles values(PLR); which are considered to be inflammatory markers, and to discuss the findings in context of neuroinflammatory ethiology of schizophrenia. Methods: Inpatient files were reviewed via complete blood count insert ignore into journalissuearticles values(CBC);, sociodemographic and clinical characteristics insert ignore into journalissuearticles values(e.g. gender, age, Body Mass Index insert ignore into journalissuearticles values(BMI);, type of psychotropic medication);. A total of 58 schizophrenic patients who underwent ECT were were compared in terms of pre- and post-ECT values of RDW, MPV, MCH, MCHC, NLR and PLR in association with type of psychotropic medication. Results: It was found that MPV, RDW, MCH and MCHC levels significantly decreased after ECT insert ignore into journalissuearticles values(p < 0.05);, but no significant difference was found in terms of NLR and PLR insert ignore into journalissuearticles values(p > 0.05);. When compared according to the type of psychotropic medication during ECT, MPV and MCHC were decreased after ECT in both typicaland atypical antipsychoticintervention groups insert ignore into journalissuearticles values(p < 0.05);. ECT-related inflammatory marker changes were more likely to be associated with atypical antipsychotic medication use during ECT. Conclusions: Our results indicate that recurrent ECT sessions caused a change in the function of the immune system which might be considered to explain the therapeutic effects of ECT in schizophrenia. 
Keywords : electroconvulsive therapy, schizophrenia, inflammatory markers, antipsychotic medication, immune system