Serum undercarboxylated osteocalcin levels are related to bone disease in hemodialysis and peritoneal dialysis patients

Authors : Medine ALPDEMİR, Vildan FİDANCI, Mehmet Fatih ALPDEMİR, Alper AZAK, Gülsevim SAYDAM, Murat DURANAY, Doğan YÜCEL

Pages : 225-234

Doi:10.18621/eurj.734216

View : 25 | Download : 16

Publication Date : 2021-05-04

Article Type : Research Paper

Abstract :Objectives: In our study, we investigated whether the undercarboxylated osteocalcin insert ignore into journalissuearticles values(ucOC); is an indicator of bone turnover for patients treated with hemodialysis insert ignore into journalissuearticles values(HD); or peritoneal dialysis insert ignore into journalissuearticles values(PD);. Furthermore, we have examined the relationships between ucOC levels and other bone inidicators such as osteocalcin insert ignore into journalissuearticles values(OC);, bone specific alkaline phosphatase insert ignore into journalissuearticles values(B-ALP);, calcitonin, vitamin D, intact parathyroid hormone insert ignore into journalissuearticles values(iPTH);, calcium insert ignore into journalissuearticles values(Ca);, phosphate insert ignore into journalissuearticles values(P);, magnesium insert ignore into journalissuearticles values(Mg); and bone mineral density insert ignore into journalissuearticles values(BMD);. Methods: Study group was consisted of 24 HD, 30 PD patients and 30 control subjects. ucOC measurements were based on precipitation of carboxylated OC with barium sulfate. After precipitation, ucOC was measured in supernatant by ELISA. Results: In chronic kidney disease insert ignore into journalissuearticles values(CKD);, increased ucOC levels were present both in HD and PD groups. The ucOC levels in HD group were higher than those of PD group. ucOC levels in samples after HD were lower than in samples before HD. But there is no difference between groups for ucOC% levels. We observed that ucOC levels for CRF were higher compared to that of control group and statistically significant. ucOC levels were positively correlated with OC, B-ALP, ALP, iPTH, P and Mg levels. There were negative and significant correlations between ucOC levels and BMD values. ucOC has a good discrimination power for both high and low turnover ROD groups. Conclusions: ucOC is a useful marker to evaluation of bone metabolism in patients undergone hemodialysis or peritoneal dialysis in end-stage renal disease.
Keywords : Renal bone disease, Hemodialysis, Peritoneal dialysis, Undercarboxylated osteocalcin, Osteocalcin, Bone mineral density