Tissue eosinophilia: a histopathological marker associated with stromal invasion but not histopathological grade in cutaneous squamous neoplasia

Authors : Nilay DUMAN, Nilay SEN KORKMAZ, Zafer EROL

Pages : 88-93

Doi:10.18621/eurj.2015.1.3.88

View : 19 | Download : 14

Publication Date : 2015-11-04

Article Type : Research Paper

Abstract :Objectives. The literature does not include any comparative study on the eosinophil count in premalignant and malignant cutaneous squamous neoplasias. Our aim was to compare the tissue eosinophilic count in actinic keratosis insert ignore into journalissuearticles values(AK); and cutaneous squamous cell carcinoma insert ignore into journalissuearticles values(SCC);. Methods. The study included 20 AK and 20 invasive SCC patients. Age, gender, and lesion location were retrospectively evaluated as clinical parameters. Histopathological parameters included density of inflammation score, lesion grade, and the lesion-associated eosinophil count per 10 high-power insert ignore into journalissuearticles values(40×); microscopic fields, all of which were compared between groups. Results. In all, 65% of the AK group had lesions with moderate inflammation, whereas 85% of the SCC group had lesions with dense inflammation insert ignore into journalissuearticles values( p =0.001);. The mean eosinophil count in the SCC group was significantly higher than that in the AK group, independent of the density of inflammation insert ignore into journalissuearticles values( p =0.000);. In addition, lesion grade was not associated with the eosinophil count in either group insert ignore into journalissuearticles values(AK group: p =0.601; SCC group: p =0.416);. Conclusions. Cutaneous SCC lesions had higher eosinophil counts than AK lesions, indicating the role of the eosinophil count as a histopathological marker of stromal invasion.
Keywords : Eosinophilia, actinic keratosis, squamous cell carcinoma, invasion