Predictive value of calculated plasma osmolality and atherogenic index of plasma for chronic limb-threatening ischemia in lower extremity artery disease

Authors : Arda Aybars PALA, Yusuf Salim URCUN

Pages : 575-583

Doi:10.18621/eurj.925688

View : 24 | Download : 11

Publication Date : 2021-11-04

Article Type : Research Paper

Abstract :Objectives: Chronic limb-threatening ischemia insert ignore into journalissuearticles values(CLTI); is the end-stage form of lower extremity artery disease insert ignore into journalissuearticles values(LEAD); whose main reason is atherosclerosis. Plasma osmolality insert ignore into journalissuearticles values(PO); and plasma lipid levels affect the development and progression of atherosclerosis directly. The purpose of this study was to investigate the predictive effect of PO and atherogenic index of plasma insert ignore into journalissuearticles values(AIP); for the development of CLTI. Methods: A total of 324 patients who were diagnosed with LEAD were analyzed retrospectively. The clinical stage of the disease was evaluated according to the Rutherford classification, and patients without CLTI were defined as “Group 1” and patients with CLTI as “Group 2”. Results: There were 248 patients insert ignore into journalissuearticles values(mean age 64.44 ± 9.05 years and 73.4% male); in Group 1, and 76 patients insert ignore into journalissuearticles values(mean age 66.62 ± 8.22 years and 76.3% male); in Group 2. In the multivariate regression analysis, CAD, PO, CRP and AIP were defined as independent predictive factors for the development of CLTI insert ignore into journalissuearticles values( p = 0.015, p < 0.001, p = 0.007, p < 0.001; respectively);. ROC curve analysis showed that, PO cut-off value for CLTI development was 293.28 mOsm/kg insert ignore into journalissuearticles values(AUC: 0.821, p < 0.001); with 75% sensitivity and 74.2% specificity, and AIP cut-off value was 0.23 insert ignore into journalissuearticles values(AUC: 0.740, p < 0.001); with 67.1% sensitivity and 68.5% specificity. Conclusions: The PO and AIP values in LEAD patients may be used as the new biomarkers of atherosclerosis progression, and therefore as predictive factors for the development of CLTI.
Keywords : atherogenic index of plasma, chronic limb threatening ischemia, osmolality, lower extremity artery disease