Hepatitis B and C virus reactivations under biologic treatments in patients with rheumatic diseases: long-term results from a single-center

Authors : Belkis Nihan COSKUN, Burcu YAĞIZ, Ezgi Sezen ÖZBOZ, Ayşe Nur TUFAN, Selime ERMURAT, Yavuz PEHLİVAN, Hüseyin Ediz DALKILIÇ

Pages : 162-168

Doi:10.18621/eurj.983279

View : 36 | Download : 14

Publication Date : 2022-03-04

Article Type : Research Paper

Abstract :Objectives: To find out the effects and prevalence of disease-modifying antirheumatic drugs insert ignore into journalissuearticles values(DMARDs); and anti-TNF agents on hepatitis B virus insert ignore into journalissuearticles values(HBV); reactivation in hepatitis B surface antigen insert ignore into journalissuearticles values(HBsAg);-positive patients with rheumatic diseases insert ignore into journalissuearticles values(RD);. Methods: This retrospective study was conducted on 1,548 RD patients. Patients’ medical records regarding immunological profiles, clinical courses, and outcomes, were obtained. In this research, the patient used conventional DMARDs insert ignore into journalissuearticles values(cDMARDs); and biological DMARDs insert ignore into journalissuearticles values(bDMARDs);. A drug exposure was considered when a patient was administered GC, cDMARDs, or bDMARDs for > 4 weeks. Serum alanine aminotransferase insert ignore into journalissuearticles values(ALT);, aspartate aminotransferase insert ignore into journalissuearticles values(AST);, and bilirubin were measured. HBsAg, HBV DNA assay, anti-HCV and HIV were identified. Results:  HBsAg was positive in 19 insert ignore into journalissuearticles values(37.3%); patients. Anti-HBs  in 5 insert ignore into journalissuearticles values(9.8%); patients and anti-HBc IgG in 35 insert ignore into journalissuearticles values(68.6%); patients were positive. All patients with HBsAg positivity were receiving antiviral prophylaxis. Anti-HCV was positive in 25.5% insert ignore into journalissuearticles values(n = 13); of individuals . There was not any reactivation among the patients. No HBV reactivation was observed.  Conclusions: Screening before treatment and give prophylaxis to patients who have occult hepatitis or hepatitis B, may be an important factor in the absence of reactivation. Hepatitis screening should be performed in all patients prior to biological treatment is initiated.
Keywords : Hepatitis, rheumatic disease, reactivation, biologic treatment, Disease modifying antirheumatic drugs, occult Hepatitis

ORIGINAL ARTICLE URL