Determinants of clinical course and mortality in COVID-19 patients with hematological disorders: real life data from a single center

Authors : Burak DEVECİ, Levent DÖŞEMECİ, Ayşe ASLAN, Gökhan ASAL, Bilge ÜSTÜN, Meltem YILDIRMER AKAR, Tayfur TOPTAS, Mine YAVUZ TAŞLIPINAR, Rabin SABA

Pages : 450-461

Doi:10.18621/eurj.1000067

View : 17 | Download : 7

Publication Date : 2022-07-04

Article Type : Research Paper

Abstract :Objectives: Patients with hematological disorders are often immunosuppressive due to underlying diseases, immunosuppressive therapies or cytotoxic chemotherapeutics. In the case of coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19);, they are at high risk of poor prognosis. Therefore, the present study aimed to evaluate the determinants of clinical course and mortality in COVID-19 patients with hematological disorders. Methods: Sixty-two hospitalized patients older than 18 years with documented COVID-19 and hematological disorders were included in the study. The clinical and laboratory data of the patients were recorded. Age, gender, overall follow-up time, duration of hospitalization, neutropenia, D-dimer levels, disease status, presence of underlying diseases, prior autologous and allogeneic stem cell transplant, immunosuppressive drug use, chemotherapy within 28 days, pneumonia, secondary bacterial infection, intubation, survival and mortality of the patients were evaluated. Results: Twenty-eight insert ignore into journalissuearticles values(45.2%); of 62 patients died due to COVID-19 and its complications. It was observed that presence of pneumonia, secondary bacterial infection, intubation, neutropenia developed after the diagnosis of COVID-19, and elevated D-dimer levels were associated with significant mortality. A D-dimer level of >1.2 μg/dL was found to be associated with 5.02 fold increase in the risk of death, with 60.7% sensitivity and 76.5% specificity. Presence of rheumatologic diseases also affected survival negatively. Conclusions: D-dimer levels have high predictive value for mortality. Considering the identified risk factors, it can be concluded that broad spectrum antibiotics can be administered earlier for prevention of high mortality rates in COVID-19 patients with underlying hematological disorders. These observations can give confidence to clinicians that delivery of effective anticancer regimens should continue during this difficult pandemic.
Keywords : COVID 19, hematological disorders, mortality