Effect of metaclopramide on urinary bladder smooth muscle contraction-relaxation mechanism

Authors : Zübeyde ERCAN, Gökhan ZORLU, Özgür BULMUŞ, İhsan SERHATLIOĞLU, Abdullah YAŞAR, Emine KACAR

Pages : 536-540

Doi:10.18621/eurj.945752

View : 19 | Download : 14

Publication Date : 2022-07-04

Article Type : Research Paper

Abstract :Objectives: Metoclopramide, a dopamine receptor antagonist, a benzamide, is a commonly used antiemetic drug in many diseases with nausea and vomiting. The aim of this study is to examine the effects of metoclopramide, which is also used in urinary system infections, on the urinary bladder contraction-relaxation mechanism. Methods: In the study, bladder tissue strips obtained from adult female Wistar rats in diestrus were placed in an isolated organ bath containing Krebs solution. The effect of metoclopramide at concentrations of 10 µM and 20 µM on sections where spontaneous contractions were observed under 1.5 g of tension was investigated. Results: Metaclopramide caused a statistically significant increase in the area under the contraction curve insert ignore into journalissuearticles values(AUC); and peak to peak insert ignore into journalissuearticles values(p-p); parameters of spontaneous bladder contractions at concentrations of 10 and 20 μM insert ignore into journalissuearticles values( p < 0.01);. Conclusions: Metaclopramide has an activator effect on spontaneous bladder contractions. This effect should be taken into consideration in clinical use, especially when used in urinary system infections.
Keywords : Metoclopramide, urinary bladder, isometric contraction, rat