Short-term treatment results of endometrial hyperplasia without atypia

Authors : Zeliha ATAK, Sakine RAHIMLI OCAKOGLU, Ayşe ERDOĞAN, Gökhan OCAKOĞLU

Pages : 491-496

Doi:10.18621/eurj.963475

View : 28 | Download : 12

Publication Date : 2022-07-04

Article Type : Research Paper

Abstract :Objectives: Endometrial hyperplasia is a pathology that often represents with abnormal uterine bleeding and develops under the influence of unopposed estrogen. In this study, the response to cyclic medroxyprogesterone acetate insert ignore into journalissuearticles values(MPA); treatment in endometrial hyperplasia without atypia, which is known to have a good response to progestagen agents, was retrospectively evaluated. Methods: Control endometrial biopsy results of 111 patients who were initiated cyclic MPA treatment due to endometrial biopsy results of endometrial hyperplasia without atypia were evaluated after 3 months of treatment. Endometrial hyperplasia free biopsy results after treatment were accepted as a successful treatment in those patient. Results: Control biopsies revealed proliferative endometrium in 37 insert ignore into journalissuearticles values(33.3%); patients, secretory endometrium in 34 insert ignore into journalissuearticles values(30.6%); patients, inactive endometrium in 9 insert ignore into journalissuearticles values(8.1%); patients, endometritis in 4 insert ignore into journalissuearticles values(3.6%); patients, endometrial hyperplasia without atypia in 26 insert ignore into journalissuearticles values(23,4%); patients, and endometrial hyperplasia with atypia in 1 insert ignore into journalissuearticles values(0.9%); patient. Our response rate to treatment was 75.7% insert ignore into journalissuearticles values(84/111); and the persistence was found to be 23.4% insert ignore into journalissuearticles values(26/111);. In patients with a positive response to treatment insert ignore into journalissuearticles values(n = 84);, the mean age was 45.15 ± 5.19 years and in patients with no response to treatment insert ignore into journalissuearticles values(n = 27); the mean age was 45.56 ± 6.41 years, and there is no difference between the two groups in terms of average age. Conclusions: Although the use of cyclic MPA in the treatment of endometrial hyperplasia without atypia is an effective treatment method, we believe that better results will be achieved in the use of more than 3 months duration.
Keywords : endometrial hyperplasia, medroxyprogesterone acetate, cyclic