How to differentiate the B.1.1.7 variant from COVID-19 in hospitalized patients?

Authors : İbrahim KOÇ, Yusuf Taha GULLU

Pages : 629-635

Doi:10.18621/eurj.1067946

View : 14 | Download : 8

Publication Date : 2022-09-04

Article Type : Research Paper

Abstract :Objectives: Little is known about COVID-19 and less about the B.1.1.7. There is a need for clinical information and tests to help doctors deal with the pandemic. This study aimed to investigate clinical and laboratory differences between hospitalized non-variant COVID-19 and the B.1.1.7 variant. Methods: Data of 173 hospitalized non-variant COVID-19 and 176 B.1.1.7 variants were retrospectively investigated. D-dimer monocyte ratio insert ignore into journalissuearticles values(DMR); and ferritin monocyte ratio insert ignore into journalissuearticles values(FMR); values were calculated by dividing D-dimer and ferritin levels to monocyte count, respectively. Monocyte eosinophil ratio insert ignore into journalissuearticles values(MER); was obtained by dividing monocyte count by eosinophil levels. Results: Clinical stay, intensive care unit insert ignore into journalissuearticles values(ICU); stay, and severe disease rates were found to be higher in the non-variant COVID-19. Eosinophil and basophil levels remained lower, whereas ferritin, FMR, and MER were more elevated in the same group. On ROC analysis, areas under the curve insert ignore into journalissuearticles values(AUC); of ferritin and FMR were found as 0.7 insert ignore into journalissuearticles values( p = 0.001); and 0.75 insert ignore into journalissuearticles values( p = 0.001);, respectively. Conclusions: The present study revealed that the B.1.1.7 variant had milder clinical manifestations, shorter clinic and ICU stay, and less severe disease rates than the non-variant COVID-19. Higher levels of ferritin, FMR, and MER may indicate the B.1.1.7 variant.
Keywords : The B 1 1 7, variant, COVID 19, monocyte eosinophil ratio, eosinophils