The relationship between platelet indices and residual SYNTAX score in patients with ST-segment elevation myocardial infarction

Authors : Emre YILMAZ, Sencer ÇAMCI

Pages : 659-669

Doi:10.18621/eurj.1123564

View : 34 | Download : 8

Publication Date : 2022-09-04

Article Type : Research Paper

Abstract :Objectives: Our aim is to investigate the relationship between thrombocyte indices, which have previously been proven to be associated with many cardiovascular diseases and adverse events, and residual SYNTAX insert ignore into journalissuearticles values(SYNergy between percutaneous coronary interventionwith TAXus and cardiac surgery); score insert ignore into journalissuearticles values(rSS); in patients with ST-segment elevation myocardial infarction insert ignore into journalissuearticles values(STEMI);. Methods: Our study included 534 patients who underwent primary percutaneous coronary intervention insert ignore into journalissuearticles values(PCI); for STEMI between January 2018 and June 2021. In our study, only patients who underwent infarct-related coronary artery revascularization in the index procedure were evaluated. First of all, patients were compared as two groups as low rSS insert ignore into journalissuearticles values(rSS ≤ 8); and high rSS insert ignore into journalissuearticles values(rSS > 8);. Our definition of platelet indices includes mean platelet volume insert ignore into journalissuearticles values(MPV);, platelet distribution width insert ignore into journalissuearticles values(PDW);, plateletcrit insert ignore into journalissuearticles values(Pct);, MPV to platelet ratio insert ignore into journalissuearticles values(MPVPR);, platelet to lymphocyte ratio insert ignore into journalissuearticles values(PLR);, and MPV to lymphocyte ratio insert ignore into journalissuearticles values(MPVLR);. Results: The mean age of the study patients was 56.4 ± 10.3 years and 78.8% were male. The high rSS group had higher C-reactive protein, lower lymphocyte count, and significantly higher platelet indices other than PLR and MPV. Among the platelet indices, MPVLR was found to have the best correlation with rSS insert ignore into journalissuearticles values(r: 0.398, p < 0.001);. MPVLR insert ignore into journalissuearticles values(AUC: 0.820, 95% CI: 0.701-0.899); was determined as the best diagnostic power index with 5.08 cut-off value in predicting high rSS with 88% sensitivity and 76% specificity insert ignore into journalissuearticles values(Youden index: 0.64);. Age, right coronary artery involvement as culprit lesion, ejection fraction, diabetes mellitus and MPVLR insert ignore into journalissuearticles values(OR: 5.966 [2.489-8.413], p < 0.001); and PDW were identified as independent risk factors for predicting high rSS. Conclusions: In conclusion, increased MPVLR is associated with high rSS in STEMI patients. There is a significant positive correlation between MPVLR and rSS. MPVLR is an independent predictor of high rSS.
Keywords : Coronary artery disease severity, incomplete revascularization, mean platelet volume to lymphocyte ratio, platelet distribution width, residual SYNTAX score

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