Pulmonary and cardiac involvement in patients with rheumatoid arthritis and ankylosing spondylitis

Authors : Ahmet Hüsrev TEKELİ

Pages : 291-300

Doi:10.18621/eurj.1108863

View : 45 | Download : 10

Publication Date : 2023-03-04

Article Type : Research Paper

Abstract :Objectives: Our aim is to study the disease activity status, laboratory data and to determine the frequency of cardiac and pulmonary findings in patients with Rheumatoid arthritis insert ignore into journalissuearticles values(RA); and ankylosing spondylitis insert ignore into journalissuearticles values(AS);. Methods: Forty-five AS patients and 78 RA patients took part in the study. The C-reactive protein insert ignore into journalissuearticles values(CRP);, erythrocyte sedimentation rate insert ignore into journalissuearticles values(ESR);, albumin, creatinine, ALT, leukocyte, neutrophil ratio, hemoglobin, platelet, rheumatoid factor insert ignore into journalissuearticles values(RF);, and anti-cyclic citrullinated peptide insert ignore into journalissuearticles values(anti-CCP); levels were measured. In addition, the patients\` thoracic computed tomography, high-resolution computed tomography insert ignore into journalissuearticles values(HRCT);, echocardiography insert ignore into journalissuearticles values(ECHO);, and pulmonary function test insert ignore into journalissuearticles values(PFT); results were evaluated. Disease activity was assessed with the Disease Activity Score-28 insert ignore into journalissuearticles values(DAS-28); in RA patients, whereas the Bath Ankylosing Spondylitis Disease Activity Index insert ignore into journalissuearticles values(BASDAI); was used in patients with AS. Results: The relationship between the anti-CCP value and gender was significant in RA patients. Significant differences were present between gender and hemoglobin value in RA and AS patients, whereas no significant differences were determined between CRP, ESR, platelet, and DAS-28 values. There was a significant difference between RF and ESR values in RA patients, whereas no significant difference was present between CRP, leukocyte, DAS-28, hemoglobin, and platelet values. Pulmonary involvement was determined in 35.7% of RA patients and 4.2% of AS patients. The difference between these was statistically significant. Conclusions: The most common pulmonary involvement is millimetric nonspecific nodule and the most common lesion among ECHO findings was left ventricular diastolic dysfunction in RA and AS patients. In RA, no significant difference was determined between PFT and DAS-28 results, as a result, the disease activity will not directly indicate pulmonary involvement.
Keywords : Rheumatoid arthritis, ankylosing spondylitis, high resolution computed tomography

ORIGINAL ARTICLE URL