The impact of radioactive iodine treatment on subclinical left ventricular dysfunction in patients treated for differentiated thyroid cancer: assessing the predictive value of presystolic wave

Authors : Asli VURAL, Oguz DİKBAS, Selahattin VURAL, Hümeyra BOZOĞLAN, Bircan SÖNMEZ

Pages : 200-206

Doi:10.18621/eurj.1200231

View : 65 | Download : 11

Publication Date : 2023-03-04

Article Type : Research Paper

Abstract :Objectives: Despite strong evidence regarding the impact of radioactive iodine insert ignore into journalissuearticles values(RAI); on the hematopoietic, genitourinary, and gastrointestinal systems, its role in the cardiovascular system needs to be clarified. We hypothesized that the presence of a presystolic wave could be predictive for cardiovascular dysfunction in subjects receiving RAI. Thus, we investigated presystolic wave presence in differentiated thyroid cancer insert ignore into journalissuearticles values(DTC); patients with and without RAI therapy after undergoing total thyroidectomy. Methods: Patients were included in the study within 1-5 years after thyroidectomy or thyroidectomy and RAI treatment. Participants were divided into three groups as follows: the first group included patients with DTC who received RAI following total thyroidectomy insert ignore into journalissuearticles values(Group 1; n = 33);, the second group included patients with DTC who did not receive RAI following total thyroidectomy insert ignore into journalissuearticles values(Group 2; n = 34);. The third group of age-matched subjects who underwent total thyroidectomy with suspicion of DTC and resulted in benign pathologies was also selected insert ignore into journalissuearticles values(Group 3; n = 37);. All subjects underwent transthoracic echocardiography. The presence of a presystolic wave was assessed with Doppler imaging of the left ventricular outflow tract. Results: Presystolic wave was more common in subjects receiving RAI insert ignore into journalissuearticles values(Group 1); compared to Group 2 insert ignore into journalissuearticles values(those without RAI); insert ignore into journalissuearticles values(90.9% vs. 61.8% respectively, p = 0.003);, and its prevalence in Group 3 was 54.1%. Multiple logistic regression analysis revealed that receiving RAI insert ignore into journalissuearticles values(OR: 4.922, 95% CI: 1.640 – 20.022, p = 0.004); was independently associated with a 5-fold higher risk for the presence of a presystolic wave. Conclusions: RAI following total thyroidectomy in patients with DTC is associated with a five-fold increase in the presence of the presystolic wave, as a proxy marker for subclinical left ventricular dysfunction.
Keywords : Differentiated thyroid cancer, radioactive iodine, echocardiography, presystolic wave

ORIGINAL ARTICLE URL