The impact of liraglutide treatment on erectile function of the diabetic rats

Authors : Serkan GÖNÜLTAŞ, Murat TÜKEN, Mehmet Gökhan ÇULHA, Suhejb SULEJMAN, Hasan Hüseyin TAVUKÇU, Yavuz BASTUG, Ege Can SEREFOGLU, Atilla SEMERCİÖZ

Pages : 759-769

Doi:10.18621/eurj.1140921

View : 63 | Download : 82

Publication Date : 2023-07-04

Article Type : Research Paper

Abstract :Objectives: Glucagon like peptide-1 insert ignore into journalissuearticles values(GLP-1); is a hormone released from intestinal L-cells following nutrient consumption. It potentiates secretion of insulin from pancreatic beta-cells thus GLP-1 analogues are used for the treatment of type-2 diabetes mellitusinsert ignore into journalissuearticles values( T2DM);. This study aims to evaluate impact of GLP-1 receptor agonist liraglutide on erectile function of diabetic rats. Methods: Male Sprague-Dawley rats insert ignore into journalissuearticles values(n = 30, 13-weeks old, 240-335 gr); were fed with fatty diet for 2-weeks and divided into 3 groups insert ignore into journalissuearticles values(n = 10 each);. The rats in the first group served as controls insert ignore into journalissuearticles values(Group C); whereas the rats in the remaining two groups were injected with streptozocin and became T2DM for forming diabetic group insert ignore into journalissuearticles values(Group D); and treatment group insert ignore into journalissuearticles values(Group DT);. Rats in group D received citrate buffer injections whereas rats in the group DT received liraglutide injections insert ignore into journalissuearticles values(0.3 mg/kg/12h); subcutaneously. Erectile functions of all rats were evaluated with intracavernosal pressure insert ignore into journalissuearticles values(ICP);/mean arterial pressure insert ignore into journalissuearticles values(MAP); measurements. Moreover, plasma sex hormone levels insert ignore into journalissuearticles values(Testosterone, FSH, LH); were measured and histological assessment of midpenile tissue were performed insert ignore into journalissuearticles values(Collagen-Type-IV, rat epithelial antigen-1, nNOS);. Results: Maximum ICP/MAP ratios were 0.790 ± 0.164, 0.263 ± 0.139 and 0.652 ± 0.131 in Group C, Group D and Group DT. Although mean ICP/MAP ratios were similar in Group C and Group DT insert ignore into journalissuearticles values( p = 0.076);, mean ICP/MAP ratio was significantly lower in Group D insert ignore into journalissuearticles values( p < 0.001);. Testosterone and FSH results were significantly lower in the Group D as well insert ignore into journalissuearticles values( p = 0.001);. Histological analyses revealed that nNOS insert ignore into journalissuearticles values( p < 0.001);, rat epithelial antigen-1 insert ignore into journalissuearticles values( p = 0.016); and muscle/collagen ratio insert ignore into journalissuearticles values( p = 0.015); were also lower in Group D, compared with the other groups. Conclusions: GLP-1 receptor agonist liraglutide demonstrated protective effects on the erectile tissues of the diabetic rats. Clinical trials are required to confirm if liraglutide treatment has similar beneficial effects on men who have T2DM.
Keywords : Erectile dysfunction, GLP 1 agonist, intracavernosal pressure, liraglutide, nNOS, type 2 diabetic rat