Investigation of the relationship between modified Glasgow prognostic score and no-reflow phenomenon in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction

Authors : Mustafa KAPLANGORAY, Kenan TOPRAK, Cihan AYDIN, Ramazan ASLAN

Pages : 894-902

Doi:10.18621/eurj.1284893

View : 55 | Download : 73

Publication Date : 2023-09-04

Article Type : Research Paper

Abstract :Objectives: No-reflow phenomenon insert ignore into journalissuearticles values(NRP); is a complication associated with poor clinical outcome in patients with ST-segment elevation myocardial infarction insert ignore into journalissuearticles values(STEMI); undergoing primary percutaneous coronary intervention insert ignore into journalissuearticles values(pPCI);. The modified Glasgow prognostic score insert ignore into journalissuearticles values(mGPS); is a novel immune-inflammatory index, derived from C-reactive protein insert ignore into journalissuearticles values(CRP); and serum albumin levels and has been shown to be associated with prognosis in heart disease. In this study we aimed to investigated the relationship between mGPS and NRP in patients undergoing pPCI for STEMI. Methods: A total of 379 patients insert ignore into journalissuearticles values(aged 59 ± 9.9 years; 54.9% male); were enrollled. The patients were divided into 2 groups:no-reflow insert ignore into journalissuearticles values(n = 72); and reflow insert ignore into journalissuearticles values(n = 307);. No-reflow was defined as thrombolysis in myocardial infarction insert ignore into journalissuearticles values(TIMI); ≤ 2 flow. The mGPS of all patients was calculated from blood samples at admission. Logistic regression analysis was performed to determine the independent predictive factors for NRP. Results: Mean age, pain to balloon duration, troponin T, white blood cell insert ignore into journalissuearticles values(WBC);, Syntax score, neutrophil to lymphocyte ratio insert ignore into journalissuearticles values(NLR);, glucose level, C-reactive protein level insert ignore into journalissuearticles values(CRP);, diabetic and female patient ratio were higher, while left ventricular ejection fraction, ST segment resolution ratio at 60 min, and serum albumin level were lower in the NRP group.Logistic regression analysis showed that WBC count [Hazard ratio insert ignore into journalissuearticles values(HR);: 0.816, 95% confidence interval insert ignore into journalissuearticles values(CI);: 0.728-0.914, p < 0.001], NLR insert ignore into journalissuearticles values(HR: 0.482, CI: 0.355-0.654, p < 0.001);, pain-to-balloon time insert ignore into journalissuearticles values(HR: 0.976, CI:0.960-0.991, p = 0.002); and mGPS insert ignore into journalissuearticles values(HR: 3.213, CI: 1.643- 6.283, p = 0.001); were independent predictive factors for NRP. Conclusions: Modified GPS is an independent predictive factor for NRP in patients undergoing pPCI for STEMI.
Keywords : ST segment elevation myocardial infarction, modified Glasgow prognostic score, no reflow phenomenon, primary percutaneous coronary intervention