Frequency of drug-associated hyperprolactinaemia: a single-center retrospective study

Authors : Elif GÜNEŞ, Mutlu GÜNEŞ

Pages : 1178-1184

Doi:10.18621/eurj.1318734

View : 57 | Download : 54

Publication Date : 2023-09-04

Article Type : Research Paper

Abstract :Objectives: One of the causes of hyperprolactinaemia insert ignore into journalissuearticles values(HP); is drug-associated HP insert ignore into journalissuearticles values(DAHP);. In this study, it was planned to investigate the frequency of DAHP. Methods: In this study, a retrospective review of 296 individuals referred to the endocrinology outpatient clinic between June 2013 and March 2018 due to elevated prolactin insert ignore into journalissuearticles values(PRL); was performed. Results: Of the 296 patients included in the study, 140 insert ignore into journalissuearticles values(47.3%); had HP insert ignore into journalissuearticles values(+);, 80 insert ignore into journalissuearticles values(27.0%); had HP insert ignore into journalissuearticles values(-);, 27 insert ignore into journalissuearticles values(9.1%); had DAHP and other causes insert ignore into journalissuearticles values(16.6%);. The causes of DAHP were as follows; sulpiride in 7 insert ignore into journalissuearticles values(25.9%); patients, risperidone in 6 insert ignore into journalissuearticles values(22.2%);, amisulpride in 4 insert ignore into journalissuearticles values(14.8%);, domperidone in 3 insert ignore into journalissuearticles values(11.1%);, haloperidol in 2 insert ignore into journalissuearticles values(7.4%);, paliperidone, olanzapine, escitalopram, duloxetine and otilonium bromide in one patient each. PRL levels in the DAHP group were higher than in the HP insert ignore into journalissuearticles values(-); group insert ignore into journalissuearticles values(respectively; median 114.6 [interquartile range insert ignore into journalissuearticles values(IQR);: 144.0], median 35 [IQR 37.3], p < 0.001);. Patients with DAHP had an increased frequency of symptoms compared to the HP insert ignore into journalissuearticles values(-); group insert ignore into journalissuearticles values(oligomenorrhoea; 42.3%, 16.4%, p = 0.007, galactorrhoea; 53.8%, 30.1%, p = 0.028, respectively);. PRL levels were higher and the frequency of clinical signs was higher in sulpiride than risperidone insert ignore into journalissuearticles values(PRL; median 195.0 [IQR 99.0], median 72.0 [IQR 57.9], p = 0.022, oligomenorrhoea; 100%, 20%, p = 0.010, respectively);. Conclusions: One of the 3 most common causes of patients referred for HP is DAHP and the most common cause of DAHP is anti-psychotic drugs. Sulpiride causes a higher rate of elevated PRL and frequency of clinical findings compared to other drugs.
Keywords : Hyperprolactinaemia, drug associated hyperprolactinaemia, anti psychotic drug