Prognostic factors in atypical carcinoid tumors

Authors : Ahmet Bilgehan ŞAHİN, Erdem ÇUBUKÇU, Adem DELİGÖNÜL, Birol OCAK, Huseyin MELEK, Buket ERKAN OZMARASALİ, Burcu CANER, Ahmet BAYRAM, Elif Ülker AKYILDIZ, Türkkan EVRENSEL

Pages : 1194-1200

Doi:10.18621/eurj.1345267

View : 69 | Download : 81

Publication Date : 2023-09-04

Article Type : Research Paper

Abstract :Objectives: Carcinoid tumors are rare neuroendocrine neoplasms of the lung. Although typical and atypical carcinoids have different clinical courses, most studies in the literature evaluate them together. Therefore, we aimed to investigate prognostic factors in patients with atypical carcinoids, excluding typical carcinoids. Methods: We included 32 patients with atypical carcinoids according to WHO 2021 criteria admitted to Uludag University Hospital. We retrospectively extracted the clinicopathological characteristics from electronic medical records. The log-rank tests were used to determine the prognostic factors on survival. Results: Median age was 57 insert ignore into journalissuearticles values(24-71); years. Pathological stages were as follows: stage I in 41%, II in 9%, III in 34%, and IV in 16%. Median Ki-67 index was 11% insert ignore into journalissuearticles values(1-50);. Median follow-up time was 46.2 insert ignore into journalissuearticles values(0.7-184.2); months. 12-month and 48-month disease-free survival insert ignore into journalissuearticles values(DFS); rates were 92.3% and 79.2%, respectively. 12-month and 48-month overall survival insert ignore into journalissuearticles values(OS); rates were 93.8% and 86.2, respectively. Receiver operating characteristic curve analysis determined the Ki-67 cut-off as 12.5%. The log-rank test indicated that Ki-67 and stage were statistically significant prognostic factors for DFS and OS. The patients with a Ki-67 index lower than 12.5% had longer DFS and OS insert ignore into journalissuearticles values( p = 0.007 and p = 0.020, respectively);. Conclusions: The Ki-67 index and 8th TNM staging have prognostic value on DFS and OS in patients with atypical carcinoids. Large-scale studies are needed to define the optimal cut-off value of Ki-67.
Keywords : Lung carcinoid, atypical carcinoid, ki 67 index, stage, survival