Antihyperglycemic, antioxidant and cytotoxic activities of Alocasia macrorrhizos (Linn.) rhizomes extract

Authors : Md Masudur RAHMAN, Md Aslam HOSSAIN, Saiful Alam SIDDIQUE

Pages : 574-579

View : 19 | Download : 7

Publication Date : 2012-12-01

Article Type : Research Paper

Abstract :Alocasia macrorrhizos insert ignore into journalissuearticles values(L.); insert ignore into journalissuearticles values(Araceae);, a coarse and erect plant that is widely cultivated to be eaten as a vegetable throughout Bangladesh, has been reported to possess a number of medicinal properties. The antihyperglycemic, antioxidant, and cytotoxic effects of the methanol extract of A. macrorrhizos rhizomes were investigated. The extract was given at a single dose insert ignore into journalissuearticles values(250 and 500 mg/kg); in alloxan-induced hyperglycemic mice. The extract at 500 mg/kg produced a significant insert ignore into journalissuearticles values(P < 0.05); decrease in the blood glucose level insert ignore into journalissuearticles values(55.49%); at 8 h of treatment when compared with the control and was comparable with the reference drug, metformin. The extract was also subjected to antioxidant potentiality and brine shrimp lethality bioassays. The IC50 value of the extract was 693.0 mg/mL and the LC50 was 188.14 mg/mL.
Keywords : Key words Antihyperglycemic, alloxan, Alocasia macrorrhizos, antioxidant activity, cytotoxicity, rhizome