In Vitro Genotoxic Effects of Benzoyl Peroxide in Human Peripheral Lymphocytes

Authors : Arzu YAVUZ, Mehmet TOPAKTAŞ, , Erman Salih İSTİFLİ

Pages : 15-24

View : 18 | Download : 8

Publication Date : 2010-12-01

Article Type : Research Paper

Abstract :The aim of the present research was to investigate the genotoxic potency of benzoyl peroxide insert ignore into journalissuearticles values(BPO);, a whitener of flour and cheese, using in vitro sister chromatid exchange insert ignore into journalissuearticles values(SCE);, chromosome aberration insert ignore into journalissuearticles values(CA);, and micronucleus insert ignore into journalissuearticles values(MN); tests in human peripheral lymphocytes. Cells were exposed to 25, 50, 75, and 100 µg/mL concentrations of BPO for 24 and 48 h. BPO induced SCEs only at the highest concentration insert ignore into journalissuearticles values(100 µg/mL); for 48 h treatment. Furthermore, BPO induced CAs at 75 and 100 µg/mL concentrations for 24 h treatment, and at all concentrations for 48 h treatment. BPO induced CAs in a dose-dependent manner for 24 and 48 h treatment periods. Increased level of MN formation induced by BPO was only observed for the 48 h treatment period at the 2 highest concentrations insert ignore into journalissuearticles values(75 and 100 µg/mL);. Statistically significant reductions in the proliferation index insert ignore into journalissuearticles values(PI); and mitotic index insert ignore into journalissuearticles values(MI); were only detected in cultures for the 48-h treatment period.
Keywords : Key words Benzoyl peroxide, human lymphocytes, sister chromatid exchange, chromosome aberration, micronucleus