Eukaryotic Transcriptional Regulatory Proteins

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Turkish Journal of Biology
Volume:24 Issue:3
Eukaryotic Transcriptional Regulatory Proteins

Eukaryotic Transcriptional Regulatory Proteins

Authors : Kemal BÜYÜKGÜZEL

Pages : 521-532

View : 20 | Download : 10

Publication Date : 2000-12-01

Article Type : Research Paper

Abstract :Transcriptional regulation is of considerable importance in the expression of eukaryotic genes, and a considerable degree of regulation is controlled at the level of mRNA synthesis. As in prokaryotic organisms, transcriptional control in eukaryotes results from an interplay between regulatory DNA sequences and site-specific DNA-binding proteins. Transcription of eukaryotic genes is influenced by various regulatory elements, termed promoters, enhancers and silencers. These regulatory elements are composed of discrete DNA sequences, which constitute binding sites for sequence-specific DNA-binding proteins. These proteins bind DNA by some common structural motifs. The motifs that are utilized by eukaryotic regulatory proteins are helix-turn-helix, zinc finger and leucine zipper.
Keywords : Regulatory proteins, DNA binding motifs, helix turn helix, zinc finger, leucine zipper, transcription of eukaryotic genes

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