The Targeting Mechanisms of Membrane Proteins

Authors : Nihat DİLSİZ

Pages : 21-28

View : 22 | Download : 10

Publication Date : 1998-12-01

Article Type : Research Paper

Abstract :This review describes what is known about the way of insertion and translocation of membrane proteins and the factors that determine these structures. The translocation of proteins across the cytoplasmic membrane in prokaryotes and that across the endosplasmic reticulum membrane in eukaryotes are similar in that both require the sinyal peptide that is attached to the amino terminus of the proteins. In general, mebrane proteins reach their final target via the secretory insert ignore into journalissuearticles values(Sec); pathway which are called Sec-dependent proteins. However, it has become clear that a few membrane proteins are not involved in Sec-pathway and these are called Sec-independent proteins.
Keywords : Protein transport, sinyal peptide, secretory protenis, membrane proteins