Reproductive biology study of dynamics of female sexual hormones: a 12-month exposure to lead acetate rat model

Authors : Eugenia DUMITRESCU, Romeo Teodor CRISTINA, Florin MUSELIN

Pages : 581-585

Doi:10.3906/biy-1402-50

View : 17 | Download : 7

Publication Date : 2014-12-01

Article Type : Research Paper

Abstract :In human and animal organisms, lead can cause reproductive problems beginning with pregnant females. The reproductive axis is particularly sensitive to lead, its influence resulting in a delayed sexual maturity due to biosynthesis suppression of the sexual steroids. An animal model study was carried out on 28 white Wistar adult female rats, divided into 3 experimental insert ignore into journalissuearticles values(E); groups that were exposed for 12 months to lead acetate in drinking water as follows: 50 ppb Pb insert ignore into journalissuearticles values(E1);, 100 ppb Pb insert ignore into journalissuearticles values(E2);, and 150 ppb Pb insert ignore into journalissuearticles values(E3);, with a control group insert ignore into journalissuearticles values(M); that received unleaded tap water. Levels of FSH, LH, estradiol, progesterone, and testosterone were evaluated in the proestrus phase by ELISA technique. Data obtained were compared by one-way ANOVA with Bonferroni correction. As a conclusion, compared to the M group, we can ascertain that lead acetate administered over a long-term period to female rats determines insert ignore into journalissuearticles values(with the exception of estradiol and progesterone);, in direct correlation with the exposure levels, the following: significantly decreased FSH, but still within physiological limits of serum levels; significantly higher serum levels of LH; significantly decreased serum levels of estradiol and progesterone; and significantly higher serum levels of testosterone.
Keywords : Reproductive biology, females, hormones, rats, lead acetate