S. cerevisiae $\beta$-glucan reduced viability of mouse hepatoma cells in vitro

Authors : ARTUR JAVMEN, AUSRA NEMEIKAITECENIENE, SAULIUS GRIGISKIS, IRENA JONAUSKIENE, MARK RUDENKOV, DARIUS KACIANAUSKAS, MYKOLAS MAURICAS

Pages : 562-0

Doi:10.3906/biy-1411-53

View : 18 | Download : 11

Publication Date : 2015-12-01

Article Type : Research Paper

Abstract :$\beta$-Glucan is a natural polymer, which is widely studied due to its multiple immunomodulatory properties. In addition, recent findings indicate potent antitumor properties of $\beta$-glucan. Saccharomyces cerevisiae, baker`s yeast, is one of the commonly used sources of $\beta$-1,3-glucan. The aim of this work was to investigate S. cerevisiae $\beta$-glucan immunomodulatory activity against cancer cells.In our experiments, BALB/c mice were fed with insoluble whole $\beta$-glucan particles, and then their blood was collected for experiments. MH-22a hepatoma cells were treated with the blood of mice fed with $\beta$-glucan, and tumor cell viability was investigated after the treatment.The obtained results demonstrated that leukocytes in vivoprimed with whole glucan particles, in combination with soluble $\beta$-glucan, decreased MH-22a hepatoma cell viabilityin vitro.Our study has indicated that $\beta$-glucan obtained from S. cerevisiae potentially primes mouse whole blood leukocytes to induce cell death of mouse hepatoma cells.
Keywords : eta Glucan, yeast, cancer, mice