Melatonin increased vitamin C and antioxidant enzyme values in the plasma, heart, liver, and kidney of Adriamycin-treated rats

Authors : Ali Ziya KARAKILÇIK, Muharrem BİTİREN, Mustafa ZERİN, Hakim ÇELİK, Nurten AKSOY

Pages : 925-931

View : 24 | Download : 14

Publication Date : 2015-12-01

Article Type : Research Paper

Abstract :Adriamycin, an anticarcinogenic agent, causes excessive production of reactive oxygen species insert ignore into journalissuearticles values(ROS);. These radicals may affect antioxidant defense systems. The present study was designed to investigate the effects of melatonin on antioxidant enzyme activities and vitamin C in Adriamycin-treated rats. In the current study, rats were divided into three groups: control, Adriamycin, and melatonin+Adriamycin groups. The control group was intraperitoneally injected physiological saline insert ignore into journalissuearticles values(0.9%); as a placebo. The Adriamycin and melatonin+Adriamycin groups were administered Adriamycin insert ignore into journalissuearticles values(25 mg/kg body weight);. The melatonin+Adriamycin group was pretreated with melatonin insert ignore into journalissuearticles values(0.5 mg/kg body weight);. Vitamin C concentration and catalase insert ignore into journalissuearticles values(CAT);, superoxide dismutase insert ignore into journalissuearticles values(SOD);, glutathione peroxidase insert ignore into journalissuearticles values(GSH-Px);, glutathione reductase insert ignore into journalissuearticles values(GR);, and myeloperoxidase insert ignore into journalissuearticles values(MPO); activities were determined in the plasma, heart, liver, and kidneys in the Adriamycin-treated rats. The activities of CAT, SOD, GSH-Px, GR, and MPO decreased generally insert ignore into journalissuearticles values(between P < 0.045 and P < 0.006); with Adriamycin treatment, but these enzymes were near to the control values with melatonin treatment. In conclusion, melatonin inhibited Adriamycin-induced ROS production through supporting antioxidant enzyme systems in the plasma, heart, liver, and kidneys of rats, and thus may play an important role against Adriamycin toxicity.
Keywords : Adriamycin, melatonin, antioxidant enzymes, heart, liver, kidney, rat