Pt(IV), Pd(II), and Rh(III) complexes induced oxidative stress and cytotoxicity in the HCT-116 colon cancer cell line

Authors : PETAR CANOVIC, JOVANA BOGOJESKI, JELENA KOSARIC, SNEZANA MARKOVIC, MARKO ZIVANOVIC

Pages : 141-147

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Publication Date : 2017-12-01

Article Type : Research Paper

Abstract :The use of transition metal complexes as appropriate analogues to cisplatin and similar anticancer drugs nowadays is of utmost importance. The inertness of Ptinsert ignore into journalissuearticles values(IV);, Pdinsert ignore into journalissuearticles values(II);, and Rhinsert ignore into journalissuearticles values(III); complexes and the choosing of convenient ligands could offer a possible advantage in comparison to Ptinsert ignore into journalissuearticles values(II); complexes. These advantages could be attributed to the better anticancer activity and fewer possible side effects. In this paper, we have chosen three complexes of different transition metal ions, [insert ignore into journalissuearticles values(TLtBu);PdIICl]ClO4, [RhIIIinsert ignore into journalissuearticles values(LH2tBu);Cl3], and [PtIVinsert ignore into journalissuearticles values(LH2tBu);Cl3]Cl insert ignore into journalissuearticles values(where TLtBu is 2,6-bis[insert ignore into journalissuearticles values(1,3-di-tert-butylimidazolin-2-imino);methyl]pyridine and LH2tBu is 2,6-bisinsert ignore into journalissuearticles values(5-tert-butyl-1H-pyrazol-3-yl);pyridine);, for biological tests. All three complexes exerted strong prooxidative and cytotoxic effects on the human colorectal colon cancer HCT-116 cell line. The Pdinsert ignore into journalissuearticles values(II); complex showed the most significant effect, while the Rhinsert ignore into journalissuearticles values(III); complex showed the least effect.
Keywords : Anticancer activity, colon cancer, cytotoxicity, oxidative stress, palladium, platinum, rhodium