The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model

Authors : Wai Feng LİM, Suriati Mohd NASİR, Lay Kek TEH, Richard Johari JAMES, Mohd Hafidz Mohd IZHAR, Mohd Zaki SALLEH

Pages : 437-448

View : 16 | Download : 13

Publication Date : 2020-12-01

Article Type : Research Paper

Abstract :Garcinia species are widely used for their slimming effects via increased fat burning and suppression of satiety. However, scientific evidence for the biological effects of Garcinia atroviridis insert ignore into journalissuearticles values(GA); is lacking. We investigated the phytochemical composition, safety profiles, and antioxidant and antiobesity effects of methanolic extracts of Garcinia atroviridis insert ignore into journalissuearticles values(MeGa); in obese female rats. Repeated dose toxicity studies were conducted according to the OECD guidelines. Upon sacrifice, haematological, biochemical, lipid profile, and serum-based metabolomics analyses were performed to evaluate metabolic expression changes and their related pathways. MeGa contains several phytochemical groups and GA fruit acids. MeGa was found to be nontoxic in both male and female rats with an oral lethal dose insert ignore into journalissuearticles values(LD50); of 2000 mg/kg. After 9 weeks of treatment, MeGa-treated obese rats had lower weight gain and better lipid profiles insert ignore into journalissuearticles values(cholesterol and triglyceride);, which correlated with the altered metabolic pathways involved in the metabolism of lipid insert ignore into journalissuearticles values(glycerophospholipid); and biosynthesis of unsaturated fatty acid. In addition, MeGa caused differential metabolism pathways of arachidonic acid and tryptophan that affect the inflammatory response and suppression of appetite. We concluded that MeGa is safe, and its slimming effects are due to the differential metabolism of lipids.
Keywords : Obesity, Garcinia atroviridis, phytochemistry, toxicity, antiobesity, metabolomics