E-cadherin might be a stage-dependent modulator in aggressiveness in pancreatic cancer cells

Authors : Esra AYDEMİR COBAN, Didem TECİMEL, Ezgi KASİKCİ, Omer Faruk BAYRAK, Fikrettin SAHİN

Pages : 230-237

View : 19 | Download : 9

Publication Date : 2020-12-01

Article Type : Research Paper

Abstract :Pancreatic ductal adenocarcinoma insert ignore into journalissuearticles values(PDAC); pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 insert ignore into journalissuearticles values(expresses the protein E-cadherin); is associated with increased overall survival in various cancers, however, E-cadherin expression in PDAC progression has remained elusive. We investigated the impact of exogenously elevated E-cadherin levels on the tumorigenicity of transduced low grade and metastatic PDAC cell lines, Panc-1 and AsPC-1, respectively. Constitutive expression of E-cadherin promoted a more hybrid E/M state in AsPC-1 cells, while it was associated with the acquisition of a more epithelial-like state in Panc1 cells. Our study suggests that E-cadherin may play differential roles in determining the metastatic characteristics of primary and metastatic pancreatic cancer cells.
Keywords : Panc 1, AsPC1, E cadherin, CRISPR dCas9 activation, pancreas cancer