Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer

Authors : Thanh Thi Ngoc NGUYEN, Minh Thi Hong TRAN, Vy Thi Lan NGUYEN, Uyen Doan Phuong Nguyen UYEN DOAN PHUONG NGUYEN, Giang Dien Thanh NGUYEN, Luan Huu HUYNH, Hue Thi NGUYEN

Pages : 284-294

View : 18 | Download : 8

Publication Date : 2020-12-01

Article Type : Research Paper

Abstract :MicroRNAs insert ignore into journalissuearticles values(miRNAs); have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer insert ignore into journalissuearticles values(BC);. Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms insert ignore into journalissuearticles values(SNPs); in DNA sequence encoding for miRNA insert ignore into journalissuearticles values(miR-SNPs); indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed.
Keywords : Breast cancer, microRNA, miRNA, single nucleotide polymorphism, SNP