Spectroscopic investigation and oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrate(III) in aqueous alkaline media: a mechanistic approach

Authors : Manjunath METI, Sharanappa NANDIBEWOOR, Shivamurti CHIMATADAR

Pages : 477-487

Doi:10.3906/kim-1307-4

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The oxidation of the anticholinergic drug atropine sulfate monohydrate by hexacyanoferrateinsert ignore into journalissuearticles values(III); in aqueous alkaline media was investigated spectrophotometrically by monitoring the decrease in absorbance of hexacyanoferrateinsert ignore into journalissuearticles values(III); insert ignore into journalissuearticles values(HCFinsert ignore into journalissuearticles values(III););. Oxidation products were identified. The oxidation mechanism was proposed from kinetic studies. The reaction constants involved in the different steps of the mechanism were calculated. The effects of added products, ionic strength, and dielectric constant of the reaction were investigated. The polymerization test revealed that oxidation occurred with intervention of free radicals. The activation parameters were evaluated.
Keywords : Kinetics of oxidation, mechanism, hexacyanoferrate III, atropine sulfate