Synthesis and antimicrobial activity of novel 2-[4-(1H-benzimidazol-1-yl)phenyl]-1H-benzimidazoles

Authors : Mehmet ALP, Ali Hakan GÖKER, Nurten ALTANLAR

Pages : 152-156

Doi:10.3906/kim-1303-81

View : 22 | Download : 6

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A new class of 2-[4-insert ignore into journalissuearticles values(1H-benzimidazol-1-yl);phenyl]-1H-benzimidazoles insert ignore into journalissuearticles values(13--22); were synthesized via cyclocondensation reaction of the substituted 1,2-phenylenediamines insert ignore into journalissuearticles values(1, 4--12); and 1-insert ignore into journalissuearticles values(4-formylpheny);-1H-benzimidazole insert ignore into journalissuearticles values(3);. The synthesized compounds were evaluated for antibacterial and antifungal activities against S. aureus, methicillin-resistant Staphylococcus aureus insert ignore into journalissuearticles values(MRSA);, and Candida albicans by the tube dilution method. Compounds 13, 15, 18, 20, and 21 have moderate antifungal activity against C. albicans.
Keywords : 1H Benzimidazole, antimicrobial activities, methicillin resistant Staphylococcus aureus, Candida albicans