Optimization of synthesizing glucose 1-phosphate by sodium tripolyphosphate as a phosphorus acylating agent using response surface methodology

Authors : Lie JIN, Fenfen CHANG, Xiaojuan WANG, Qing CAO

Pages : 765-774

Doi:10.3906/kim-1210-15

View : 12 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :With glucose as the starting material, sodium tripolyphosphate as the phosphorus acylating agent, and urea as the catalyst, glucose 1-phosphate was synthesized and its properties were analyzed. The synthesis conditions were selected according to the phosphorus content and optimized through the response surface methodology insert ignore into journalissuearticles values(RSM);, based on a 3-level, 3-variable Box--Behnken experimental design. The results showed that the phosphorus content of glucose 1-phosphate was 8.12% using a reaction temperature of 70 °C, a molar ratio of glucose to sodium tripolyphosphate of 1.54:1, and catalyst amount of 3.7 g. It coincided well with the experimental value insert ignore into journalissuearticles values(8.34%);. The structure of the product was confirmed by IR, UV, and 1H NMR spectra; electrical conductivity; TG; and DTA. The proposed method has high phosphorus content and low toxicity.
Keywords : Synthesis, sodium tripolyphosphate, glucose 1 phosphate, response surface methodology