Biotinylated N,N`-diarylureas as probes for the activation of adenosine monophosphate-activated kinase (AMPK)

Authors : Vitaliy SVIRIPA, Michael D CONROY, Wen ZHANG

Pages : 473-479

Doi:10.3906/kim-1302-78

View : 18 | Download : 2

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Biotinylated analogs of drug candidates provide useful tools for studying the drug--target protein interactions. Polyhalogenated N,N`diarylureas are potent activators of adenosine monophosphate-activated kinase insert ignore into journalissuearticles values(AMPK); and potentially promising agents for the treatment of cancer. Various biotinylated versions of these N,N`-diarylureas were synthesized and evaluated in AMPK-activation studies.
Keywords : Adenosine monophosphate activated kinase, biotinylated N, N` diarylureas