Umpolung strategy: advances in catalytic C-C bond formations

Authors : Serkan EYMUR, Mehmet GÖLLÜ, Cihangir TANYELİ

Pages : 586-609

Doi:10.3906/kim-1303-85

View : 18 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :This mini-review examines the recent advances in umpolung strategy, devised originally by Corey and Seebach. Although numerous stoichiometric variants have been published to date, this article covers just the catalytic C-C bond forming reactions due to their major benefits such as atom economy, less pollution, and workable simplicity. In the context of umpolung, the studies are evaluated under 3 main titles: enzyme, N-heterocyclic carbene, and cyanide ion catalyzed reactions. In particular, enzyme and NHC catalyzed reactions mainly involve asymmetric applications.
Keywords : Umpolung, thiamine pyrophosphate TPP, N heterocyclic carbene, asymmetric synthesis