Terpenoids, essential oil composition, fatty acid profile, and biological activities of Anatolian Salvia fruticosa Mill

Authors : Gülaçtı TOPÇU, Mehmet ÖZTÜRK, Tuba KUŞMAN

Pages : 619-632

Doi:10.3906/kim-1303-25

View : 21 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The hexane and dichloromethane extracts, obtained by re-extraction of the methanol extract of Salvia fruticosa Mill., afforded 7 diterpenoids insert ignore into journalissuearticles values(carnosol, carnosic acid, carnosic acid 12-methyl ether, rosmadial, isorosmanol, ferruginol, and manool);, 4 triterpenoids insert ignore into journalissuearticles values(a -amyryltetracosanoate, oleanolic acid, ursolic acid, and erythrodiol);, a steroid insert ignore into journalissuearticles values(3-acetylsitosterol);, and a flavone insert ignore into journalissuearticles values(salvigenin);. The galls insert ignore into journalissuearticles values(apples); of the collected plant were separately extracted with hexane to afford fatty acids composed mainly of oleic acid insert ignore into journalissuearticles values(29%);, palmitoleic acid insert ignore into journalissuearticles values(29%);, and stearic acid insert ignore into journalissuearticles values(23.20%);, which exhibited high anticholinesterase activity, particularly against BChE. The essential oil, obtained from the aerial parts of the plant, exhibited high AChE inhibitory activity, consisting of mainly 1,8-cineol insert ignore into journalissuearticles values(58.89%);. The antioxidant activity according to 6 complementary tests and anticholinesterase potential of the methanol extracts and triterpenoids a-amyryltetracosanoate, oleanolic acid, ursolic acid, and sitosterol acetate were also investigated, and methanol extract exhibited the highest antioxidant and anticholinesterase activity, surpassing the other tested extracts and pure compounds.
Keywords : Lamiaceae, Salvia fruticosa, secondary metabolites, abietane diterpenoids, triterpenoids, essential oil, fatty oil, antioxidant, anticholinesterase