Preparation of 2-(N,N-dialkylamino)-2,4,6- cycloheptatrien-1-one derivatives from an isocyanide, a primary amine, propionaldehyde, and tropolone via Ugi-Smiles coupling reaction in the presence of silica nanoparticles

Authors : Abdolhossain MASSOUDI, Issa AMINI, Ali RAMAZANI

Pages : 779-787

Doi:10.3906/vet-1302-46

View : 15 | Download : 6

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The use of Smiles rearrangement in Ugi-type couplings with tropolone allows very straightforward multicomponent formation of 2-insert ignore into journalissuearticles values(N,N-dialkylamino);-2,4,6-cycloheptatrien-1-one derivatives. The 4-component reaction of isocyanides, tropolone insert ignore into journalissuearticles values(2-hydroxy-2,4,6- cycloheptatrien-1-one);, primary amines, and propionaldehyde in the presence of silica nanoparticles insert ignore into journalissuearticles values(silica NPs, ca. 42 nm); proceeds easily in methanol to form the title compounds in a new Ugi--Smiles-type reaction.
Keywords : Ugi type coupling, tropolone, isocyanides, primary amines, silica NP, Ugi Smiles type reaction