Chemical and biotransformation of Gelomulide F: a rare diterpene lactone

Authors : Humaira Yasmeen GONDAL, And Muhammad Iqbal CHOUDHARY

Pages : 759-763

Doi:10.3906/yer-1208-3

View : 21 | Download : 13

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Chemical and biotransformations of a rare diterpene lactone, Gelomulide F insert ignore into journalissuearticles values(1);, from the cytotoxic extract of leaves of Suregada multiflora were studied. Fermentation of compound 1 with Sachromyces cerevisiae transformed it to Gelomulide D insert ignore into journalissuearticles values(2); and E insert ignore into journalissuearticles values(3);, whereas its treatment with 2N KOH yielded Gelomulide D insert ignore into journalissuearticles values(2);. In addition, a novel compound insert ignore into journalissuearticles values(4); was obtained by its diastereo and chemoselective reduction with NaBH4. All of these compounds were characterized on the basis of extensive 1H-NMR, 13C-NMR, 2D NMR, and mass spectral analyses.
Keywords : Diterpene lactone, Gelomulide, Suregada multiflora, Sachromyces cerevisiae, diastereo and chemoselective reduction