Design, synthesis, and biological evaluation of indole-based 1,4-disubstituted piperazines as cytotoxic agents

Authors : Meriç KÖKSAL AKKOÇ, Mine YARIM YÜKSEL, İrem DURMAZ

Pages : 515-525

Doi:10.3906/vet-1303-36

View : 15 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of 3-[insert ignore into journalissuearticles values(4-substitutedpiperazin-1-yl);methyl]-1H-indole derivatives were synthesized, and their structures were confirmed by spectral analysis. All the compounds were tested for their cytotoxic activity in vitro against 3 human tumor cell lines: human liver insert ignore into journalissuearticles values(HUH7);, breast insert ignore into journalissuearticles values(MCF7);, and colon insert ignore into journalissuearticles values(HCT116);. Among the designed derivatives, most of the compounds showed significant cytotoxicity against liver and colon cancer cell lines with lower IC50 concentrations than the standard drug 5-fluorouracil. Compound 3s, with 3,4-dichlorophenyl substituent on the piperazine ring, was the most active in suppressing the growth of all screened cancer cells.
Keywords : Anticancer activity, cytotoxicity, Mannich base, indole, 1, 4 substituted piperazines