Determination of lidocaine based on electrocatalysis of a chemically modified electrode

Authors : Gamze TAN, Gülçin BOLAT, Mehmet Ali ONUR, Serdar ABACI

Pages : 593-600

Doi:10.3906/sag-1302-131

View : 18 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin insert ignore into journalissuearticles values(Hb); immobilized on gold film modified with a self-assembled monolayer insert ignore into journalissuearticles values(SAM); of 3-mercaptopropionic acid insert ignore into journalissuearticles values(MPA);. According to the results of voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity and good electrocatalytic activity for the reduction of lidocaine, motivating us to construct drug biosensors. With this study, a new electroanalytical procedure is proposed for the determination of lidocaine level in medical applications or therapeutic formulations containing lidocaine as the active ingredient.
Keywords : Lidocaine, hemoglobin, chemically modified electrodes, drug biosensor, electrochemistry