Silica nanoparticles as a high efficient catalyst for the one-pot synthesis of 3-oxo-3-phenylpropanamid derivatives from isocyanides, phenylacetaldehyde and secondary amines

Authors : Ali RAMAZANI, Kourosh DASTANRA, Fatemeh Zeinali NASRABADI

Pages : 467-476

Doi:10.3906/sag-1210-28

View : 16 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Reaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2-oxo-2-phenylacetaldehyde and a secondary amine in the presence of silica nanoparticles, proceeds smoothly at room temperature to afford ketoamide derivatives in high yields.
Keywords : Silica nanoparticles, multicomponent reaction, isocyanide, 2 oxo 2 phenylacetaldehyde, secondary amine, iminium ion