Novel biologically active glycosides from the aerial parts of Cephalaria gazipashensis

Authors : Nazlı Böke Sarikahya And Süheyla KIRMIZIGÜL

Pages : 323-334

Doi:10.3906/tar-1208-58

View : 12 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Two new triterpene glycosides, 3-O-b-D-glucopyranosyl- insert ignore into journalissuearticles values(1\to 4);-b-D-xylopyranosyl-insert ignore into journalissuearticles values(1\to 3);-a-L-rhamnopyranosyl- insert ignore into journalissuearticles values(1\to 3);-a-L-arabinopyranosyl olean-12-ene 28-O-b -D- glucopyranosyl-insert ignore into journalissuearticles values(1\to 6);-b-D-glucopyranosyl ester insert ignore into journalissuearticles values(gazipashoside A, 1); and 3-O-b-D-glucopyranosyl-insert ignore into journalissuearticles values(1\to 4);-b-D-xylopyranosyl- insert ignore into journalissuearticles values(1\to 3);-a-L-rhamnopyranosyl-insert ignore into journalissuearticles values(1\to 2);-a-L-arabinopyranosyl hederagenin 28-O-b -D-glucopyranosyl-insert ignore into journalissuearticles values(1\to 6);-b-D-glucopyranosyl ester insert ignore into journalissuearticles values(gazipashoside B, 2);, were isolated together with 11 known compounds including 7 triterpene, 1 flavonoid, and 3 iridoidal metabolites from the aerial parts of Cephalaria gazipashensis insert ignore into journalissuearticles values(Dipsacaceae);. The structures of all compounds were elucidated by extensive evaluation of the spectroscopic data insert ignore into journalissuearticles values(1D- and 2D- NMR, HRESI-MS);, as well as chemical examinations. The antimicrobial effects of all pure compounds were tested against gram-positive and gram-negative bacteria. The results indicated that the 2 new triterpene glycosides might be acceptable as antimicrobial active agents.
Keywords : Gazipashoside A, gazipashoside B, Dipsacaceae, Cephalaria gazipashensis, triterpene glycoside, antimicrobial activity