One-pot synthesis of fully substituted 1,3,4-oxadiazole derivatives from aromatic carboxylic acids, cyclobutanone and N -isocyaniminotriphenylphosphorane

Authors : Mohsen VALIZADEH HOLAGH, Abel Mohammadali oglu MAHARRAMOV

Pages : 179-188

Doi:10.3906/zoo-1202-16

View : 12 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Reactions of N-isocyaniminotriphenylphosphorane with cyclobutanone in the presence of aromatic insert ignore into journalissuearticles values(or heteroaromatic); carboxylic acids proceeded smoothly at room temperature and in neutral conditions to afford sterically congested 1-insert ignore into journalissuearticles values(5-aryl-1,3,4-oxadiazol-2-yl);- 1-cyclobutanol derivatives in high yields. The reaction proceeded smoothly and cleanly under mild conditions and no side reactions were observed. The structures of the products were deduced from their IR, 1HNMR, and 13CNMR spectra, and mass spectrometry.
Keywords : N isocyaniminotriphenylphosphorane, intramolecular aza Wittig reaction, 1, 3, 4 oxadiazole, aromatic carboxylic acid, cyclobutanone