Synthesis, characterization, and antimicrobial activity of a new pyrimidine Schiff base and its Cu(II), Ni(II), Co(II), Pt(II), and Pd(II) complexes

Authors : Mehmet GÜLCAN, Mehmet SÖNMEZ, İsmet BERBER

Pages : 189-200

Doi:10.3906/sag-1301-32

View : 12 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A new Schiff base, {1-[insert ignore into journalissuearticles values(5-bromo-2-hydroxy-benzylidene);- amino]-4-phenyl-2-thioxo-1,2-dihyro-pyrimidin-5-yl}-phenyl-methanone, was synthesized from N-amino pyrimidine-2-thione and 5-bromsalicylaldehyde. Metal complexes of the Schiff base were prepared from acetate salts of Cuinsert ignore into journalissuearticles values(II);, Niinsert ignore into journalissuearticles values(II);, Coinsert ignore into journalissuearticles values(II);, Pdinsert ignore into journalissuearticles values(II);, and PtCl2 in methanol. The chemical structures of the Schiff base ligand and its metal complexes were confirmed by spectroscopic analysis. All of the compounds were evaluated for their antimicrobial against 4 gram-positive bacteria, 1 gram-negative bacterium, and 3 yeast strains. The Schiff base and the Cuinsert ignore into journalissuearticles values(II); and Coinsert ignore into journalissuearticles values(II); complexes showed good biological activity against all tested bacteria and yeast strains.
Keywords : N aminopyrimidine 2 thione, 5 bromosalicylaldehyde Schiff base, metal complexes, antimicrobial activity