Synthesis, crystal structure, and antioxidant properties of novel 1,2,4-triazol-5-ones containing 3,4-dimethoxyphenyl and 3,4-dihydroxyphenyl moiety

Authors : Yasemin ÜNVER, Sevgi MEYDANAL, Kemal SANCAK, Dilek ÜNLÜER

Pages : 265-277

Doi:10.3906/sag-1203-100

View : 18 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of new 4-insert ignore into journalissuearticles values(3,4-dimethoxyphenethyl);-5-akyl/aryl-2H- 1,2,4-triazol-3insert ignore into journalissuearticles values(4H);-ones insert ignore into journalissuearticles values(3a-g); was obtained by the reaction of ethyl 2-insert ignore into journalissuearticles values(ethoxy);insert ignore into journalissuearticles values(alkylidene/arylidene);hydrazinecarboxylate insert ignore into journalissuearticles values(1); and 2-insert ignore into journalissuearticles values(3,4-dimethoxyphen- yl);ethanamine insert ignore into journalissuearticles values(2);. Compounds 4a-f and 5 were synthesized from the reaction of corresponding compounds 3a-f and 3g with BBr3, respectively. With elemental analysis, IR, 1H-NMR, and ^{13C-NMR spectral data, 14 newly synthesized compounds were characterized. The structure of compound 3a was inferred through IR, ^1H- and ^{13}C-NMR, elemental analysis, and X-ray spectral techniques. In addition, the newly synthesized chemicals were screened for their antioxidant properties. Among the chemicals tested, 4a, 4c, 4d, 4f, and 5 exhibited the highest degree of antioxidant activity.
Keywords : Synthesis, 1, 2, 4 triazole 3 one, antioxidant activity, X ray