Synthesis and anti-Helicobacter pylori activity of (4-nitro-1-imidazolylmethyl)-1,2,4-triazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles

Authors : Asal Fallah TAFTI, Tahmineh AKBARZADEH, Parastoo SANIEE

Pages : 307-316

Doi:10.3906/sag-1208-4

View : 13 | Download : 14

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of [insert ignore into journalissuearticles values(4-nitro-1H-imidazol-1-yl);methyl]-1,2,4- triazoles and 1,3,4-thiadiazoles were prepared and evaluated for their activity against sensitive and resistant H. pylori strains. Study of the structure-activity relationship of these series of compounds indicated that the type of nitroimidazole moiety and the pendent group on the heteroaryl analog dramatically impact the anti-H. pylori activity. In triazole series, compound 5d, containing a 4-methyl phenyl group on the triazole ring, was the most potent compound tested against both metronidazole-sensitive and -resistant strains at a concentration of 8 m g.
Keywords : 4 Nitroimidazole, 1, 2, 4 triazoles, 1, 3, 4 thiadiazoles, 1, 3, 4 oxadiazoles, anti H pylori activity