Synthesis and in vitro antimycobacterial activities of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/ nonsubstituted acetophenone) hydrazone

Authors : Semra UTKU, Mehtap GÖKÇE, Gönül ASLAN, Gül BAYRAM

Pages : 331-339

Doi:10.3906/zoo-1204-24

View : 22 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The difficulty in managing tuberculosis includes the prolonged duration of the treatment, the emergence of drug resistance, and coinfection with HIV/AIDS. Tuberculosis control requires new drugs that act on novel drug targets to help in combating resistant forms of Mycobacterium tuberculosis and reduce the treatment duration. For this purpose, 6-substituted-3insert ignore into journalissuearticles values(2H);-pyridazinone-2-acetyl-2- insert ignore into journalissuearticles values(substituted/nonsubstituted acetophenone); hydrazone derivatives were synthesized and their structures were elucidated by elemental analyses, IR, and 1H-NMR. The in vitro antimycobacterial activities of synthesized compounds 5a-l were determined by the agar proportion method against Mycobacterium tuberculosis H37Rv. Among the target compounds, 5b and 5f exhibited the best antimycobacterial activity, with a MIC value of 5 m g/mL.
Keywords : 3 2H, Pyridazinone, acetophenone hydrazone, antimycobacterial activity, antitubercular drugs