Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives

Authors : Oya ÜNSAL TAN, Keriman ÖZADALI, Özgür YEŞİLYURT

Pages : 121-130

Doi:10.3906/vet-1204-32

View : 16 | Download : 10

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Some isoxazolo[4,5-d]pyridazin4insert ignore into journalissuearticles values(5H);-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i insert ignore into journalissuearticles values(25 mg/kg); showed analgesic profiles similar to that of morphine insert ignore into journalissuearticles values(5 mg/kg);.
Keywords : Isoxazolo 4, 5 d pyridazin 4 5H, one, hot plate test, writhing test, analgesic effect