IAD Index of Academic Documents
  • Home Page
  • About
    • About Izmir Academy Association
    • About IAD Index
    • IAD Team
    • IAD Logos and Links
    • Policies
    • Contact
  • Submit A Journal
  • Submit A Conference
  • Submit Paper/Book
    • Submit a Preprint
    • Submit a Book
  • Contact
  • Turkish Journal of Chemistry
  • Volume:34 Issue:6
  • Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives

Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives

Authors : Hacer BAYRAK, Ahmet DEMİRBAŞ, Hakan BEKTAŞ, Şengül ALPAY KARAOĞLU
Pages : 835-846
View : 20 | Download : 7
Publication Date : 0000-00-00
Article Type : Research Paper
Abstract :The synthesis of ethyl [3-insert ignore into journalissuearticles values(cyanomethyl);-5-alkyl-4H-1,2,4-triazol- 4-yl]carbamates insert ignore into journalissuearticles values(2a-d); was performed starting from ethyl 2-[ethoxyinsert ignore into journalissuearticles values(4- insert ignore into journalissuearticles values(aryl);methylene]hydrazinecarboxylates insert ignore into journalissuearticles values(1a, 1b);. The treatment of 2a with thiosemicarbazide afforded ethyl [3-[insert ignore into journalissuearticles values(5-amino-1,3,4-thiadiazol- 2-yl);methyl]-5-insert ignore into journalissuearticles values(4-nitrophenyl);-4H-1,2,4-triazol-4-yl]carbamates insert ignore into journalissuearticles values(3a);, whereas compound 2b produced 5-{[4-amino-5-insert ignore into journalissuearticles values(4-methylphenyl);- 4H-1,2,4-triazol-3-yl]methyl}-1,3,4-thiadiazol-2-amine insert ignore into journalissuearticles values(3b); in the same reaction conditions. The treatment of tert-butyl 2-[2-insert ignore into journalissuearticles values(4-chlorophenyl);-1-ethoxyethylidene]hydrazinecarboxylate insert ignore into journalissuearticles values(5); with malonohydrazide or cyanoacethydrazide gave the corresponding 1,2,4-triazol-ylcarbamate derivatives insert ignore into journalissuearticles values(6 or 9);; then the hydrolysis of these compounds resulted in the formation of 3-{[4-amino-5-insert ignore into journalissuearticles values(4- chlorobenzyl);-4H-1,2,4-triazol-3-yl]methyl}-5-insert ignore into journalissuearticles values(4-chlorobenzyl);-4H- 1,2,4-triazol-4-amine insert ignore into journalissuearticles values(7); and [4-amino-5-insert ignore into journalissuearticles values(4-chlorobenzyl);-4H- 1,2,4-triazole-3-yl]acetonitrile insert ignore into journalissuearticles values(10);, respectively. The synthesis of the Schiff base derivatives 3-insert ignore into journalissuearticles values(4-chlorobenzyl);-5-{[5-insert ignore into journalissuearticles values(4-chloroben- zyl);-4-[insert ignore into journalissuearticles values(2-hydroxyphenyl-methylene);amino]-4H-1,2,4-triazol-3-yl]methyl} -N-insert ignore into journalissuearticles values(2-hydroxyphenylmethylene);-4H-1,2,4-triazol-4-amine insert ignore into journalissuearticles values(8);, and insert ignore into journalissuearticles values(5-insert ignore into journalissuearticles values(4-chlorobenzyl);-4-{[insert ignore into journalissuearticles values(2,6-dichlorophenyl);methylene]amino}-4H-1,2,4- triazol-3-yl);acetonitrile insert ignore into journalissuearticles values(12); was performed from the reaction of compounds 7 and 10 with salicyl aldehyde insert ignore into journalissuearticles values(for 8); or 2,6-dichlorobenzaldehyde insert ignore into journalissuearticles values(for 12);, respectively. The treatment of compounds 5 or 10 with thiosemicarbazide gave 5-{[4-amino-5-insert ignore into journalissuearticles values(4-chlorobenzyl);-4H-1,2,4-triazol- 3-yl]methyl}-1,3,4-thiadiazol-2-amine insert ignore into journalissuearticles values(11);. All the newly synthesized compounds were screened for their antimicrobial activities and were found to possess good or moderate antimicrobial activity.
Keywords : 1, 3, 4 Thiadiazole, 1, 2, 4 triazole, carbamate, antimicrobial activity

ORIGINAL ARTICLE URL
VIEW PAPER (PDF)

* There may have been changes in the journal, article,conference, book, preprint etc. informations. Therefore, it would be appropriate to follow the information on the official page of the source. The information here is shared for informational purposes. IAD is not responsible for incorrect or missing information.


Index of Academic Documents
İzmir Academy Association
CopyRight © 2023-2025