Biotransformation of danazol by Fusarium solani and Gibberella fujikuorii, and prolyl endopeptidase inhibition studies of transformed products

Authors : Muhammad Iqbal CHOUDHARY

Pages : 945-952

Doi:10.3906/sag-1206-72

View : 15 | Download : 9

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Biotransformation of danazol insert ignore into journalissuearticles values(17b-hydroxy-17a-pregna-2,4-dien-20-yno-[2,3-d] isoxazole); insert ignore into journalissuearticles values(1); on fermentation with Fusarium solani yielded 17b-hydroxy-2-insert ignore into journalissuearticles values(hydroxymethyl);-17a -pregn-4-en-20-yn-3-one insert ignore into journalissuearticles values(2); and 17b -hydroxy-2-insert ignore into journalissuearticles values(hydroxymethyl);-17a-pregna-1,4-dien-20-yn-3-one insert ignore into journalissuearticles values(3);, while the fermentation of 1 with Gibberella fujikuorii yielded compound 2 only. The structures of these compounds were deduced on the basis of modern spectroscopic techniques. Prolyl endopeptidase inhibition activities of danazol insert ignore into journalissuearticles values(1); and its transformed products 2 and 3 are also studied.
Keywords : Biotransformation, danazol, Fusarium solani, Gibberella fujikuorii, prolyl endopeptidase PEP, inhibition assay