Preparation and characterization of anticancer drug-loaded implantable PLGA microparticles

Authors : Meltem ÇETİN, İmran VURAL, Alptuğ ATİLA, Yücel KADIOĞLU

Pages : 509-516

Doi:10.3906/sag-1208-86

View : 21 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :This article describes the preparation and characterization of anticancer drug-loaded polyinsert ignore into journalissuearticles values(lactide-co-glycolide); insert ignore into journalissuearticles values(PLGA); microparticles. PLGA microparticles loaded with doxorubicin HCl insert ignore into journalissuearticles values(DOX); were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was performed by using Glioma RG2 cancer cells to investigate the cytotoxicity of DOX-loaded PLGA microparticles. The DOX-loaded PLGA microparticles had an average diameter of 500 \pm 9 nm. The DOX encapsulation efficiency and drug loading were 22.75% and 0.78%, respectively. DOX-loaded PLGA microparticles displayed a significant cytotoxicity toward the RG2 cells as compared to the unloaded PLGA
Keywords : Turk J Chem, 34, 2010, 509 516 Turk J Chem, vol 34, iss 4